Our lab develops and employs advanced vibrational spectroscopic techniques to investigate surface reactivity with nanometer-scale resolution. By combining vibrational nanospectroscopies (AFM-IR, sSNOM, TERS) and solid-state NMR spectroscopy, we explore how chemical activity varies across different surface sites within single nanoparticles. Using vibrational probe molecules that selectively bind to the catalyst’s surface, we generate spatially resolved chemical maps that reveal structure–reactivity relationships at the single particle level. This correlative approach enables a deeper understanding of surface heterogeneity in systems ranging from 2D materials to supported catalysts.